2375 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... : • Cytokine Release ... • Cathepsin G release ... overload, PCC to reverse ... Differentiation #Syndrome
BRASH Syndrome

B - Bradycardia
R - Renal failure
A - AV nodal blockade
S - Shock
H - Hyperkalemia

Typical ECG
BRASH Syndrome ... digoxin, consider reversal ... DrEricStrong #BRASH #Syndrome
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
hypercapnia (acute reversal ... hyperaldosteronism) • Severe ... Cushing syndrome ... Congenital AME syndrome ... alkalosis: other • Severe
Paget-Schroetter syndrome. Venous compression is evidenced with a provocation test (elevation, abduction and pronation)

20 y. Started
Paget-Schroetter syndrome ... thoracic outlet syndrome ... even see flow reversal
Distal Radius Fracture 
Distal radius fracture is the most common orthopedic injury. Here's a quick summary.
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• Smith ("reverse ... carpal tunnel syndrome
Paget-Schroetter syndrome. Venous compression is evidenced with a provocation test (elevation, abduction and pronation)

20 y. Started
Paget-Schroetter syndrome ... thoracic outlet syndrome ... even see flow reversal ... Paget #Schroetter #syndrome ... thoracic #outlet #syndrome
Fever Patterns - Differential Diagnosis Framework

Continuous Fever:
Temp > 38°C with only 1 degree fluctuation in 24
Other Recurrent Fevers ... disease • Behcet's syndrome ... Inversus Pattern: Reversal ... • Hyper-IgD syndrome ... receptor-associated periodic syndrome
Differential diagnosis of the reversed halo sign (RHS). AIA, angioinvasive aspergillosis; AIS, adenocarcinoma in situ; COP,
diagnosis of the reversed ... immunedeficiency syndrome
The Neurological Evaluation of a Comatose Patient

Definition:
 • Coma: a state of unresponsiveness; the absence of
Unresponsive wakefulness syndrome ... • Locked-in syndrome ... Pathophysiology: • Severe ... deviation: Not reversed
B-Lines on Lung POCUS

PE is LEAST likely to show B lines. Juxtaposition of fluid droplets &
multiple foci of reverb ... alveolar interstitial syndrome