69 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Cell Disease Vaso-occlusive ... #Joint #Pain #SickleCell ... #Disease #differential ... #diagnosis #causes
Chronic Joint Pain - Differential Diagnosis Algorithm 
Intra-Articular
 - Bone
     • Stress
Chronic Joint Pain ... - Differential ... Diagnosis Algorithm ... Osgood-Schlatter Disease ... #Orthopedics #Causes
Rheumatoid arthritis (RA): Pathogenesis and Joint diseases features
 • RA affects 1% of population, women >
diseases features ... pain, swelling, ... in subchondral bone ... pain), especially ... #symptoms #diagnosis
Aortitis - Diagnosis and Workup
Clinical History:
 - Fever, weight loss, deterioration of general health
 - Aortic
regurgitation - Pain ... hypertension) - Symptoms ... Inflammatory diseases ... Nivolumab, GM-CSF ... #Workup #Differential
Approach to Joint Pain - Diagnostic Framework

1) Chronicity
2) Inflammatory vs Non-Inflammatory
3) Number of Joints Involved

1) Chronicity:
Pain - Diagnostic ... ), RA, crystal disease ... #Joint #Pain #MSK ... rheumatology #approach #workup ... #differential #
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
or nerve root Symptoms ... of Joint Disease ... #approach #workup ... #differential # ... diagnosis #arthritis
Acute and Chronic Causes of Dyspnea - Differential Diagnosis
Pulmonary/Chest Wall:
 • Acute: Trauma, COPD exacerbation, Asthma
Causes of Dyspnea ... - Differential ... decompensated CHF ... Depression - VA Joint ... #Causes #Differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Differential Diagnosis ... noninflammatory Signs ... constitutional symptoms ... weeks) Can Be Caused ... #pain #Differential
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
ALP) Elevation - Differential ... Diagnosis Algorithm ... Intestine - Other causes ... - Bone symptoms ... - Pain -> RUQ
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
Most cases diagnosed ... -> chronic pain ... Malnutrition • Wilson's disease ... mineralization Symptoms ... Phosphatase: • Other causes