12 results
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Workup History ... pylori test (GI symptoms ... candidate) - Bone ... #Causes #Workup ... #hematology
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... evaluation or workup ... for specific symptoms ... 1,500 cells/µL Workup ... #Differential #diagnosis
Paget’s Disease: Complications
Abnormal Osteoclasts cause excessive bone turnover -> Incr bone resorption, Incr (abnormal) bone formation

MSK
Abnormal Osteoclasts cause ... Heart Failure (CHF ... Nerve Palsies • Disordered ... pathophysiology #diagnosis ... #signs #symptoms
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
with no early symptoms ... lymphoproliferative disorders ... Warm AIHA • Bone ... #workup #oncology ... #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
are a group of disorders ... formed or don’t work ... age 70 years Symptoms ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
Hematologic disorder ... constitutional symptoms ... , or a related disorder ... #Significance #hematology ... #diagnosis #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... chronic onset of symptoms ... -> AML: Blast crises ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
= Hypocellular bone ... and petechiae Causes ... • Improve the symptoms ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... ingestion • B symptoms ... Hodgkin Lymphoma Workup ... anymore • Routine bone ... #oncology #management
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
Cryofibrinogenemia Symptoms ... cryoglobulinemia Associated Disorders ... Cryofibrinogenemia Diagnosis ... cryoglobulins • Negative causes ... Cryofibrinogenemia #diagnosis