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hematology management leukemia anemia aplastic chronic classification cll differential differentiation essential et hepatitis hodgkins injury liver lymphocytic lymphoma mds myelodysplasia
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... : >3 symptoms, or ... sepsis), PE, DAH, CHF ... #APML #diagnosis ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
, APML, CLL Acute ... : Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... age 70 years Symptoms ... Workup: • Complete ... #diagnosis #hematology ... #oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
with no early symptoms ... Warm AIHA • Bone ... • Richter’s Syndrome ... #workup #oncology ... #hematology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
= Hypocellular bone ... and petechiae Causes ... • Improve the symptoms ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular ... Causes of Acute ... , Congestion/CHF ... hemolysis) • ALP: Bone ... #algorithm #hepatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
ingestion • B symptoms ... Hodgkin Lymphoma Workup ... lymph node biopsy (diagnostic ... anymore • Routine bone ... #oncology #management
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... When present, symptoms ... 450,000/microL • Bone ... transformation into MDS or AML ... • Treatment algorithms
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