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management differential algorithm hepatology liver lung lupus medications rheumatology table acidosis aclf acute amiodarone chronic cirrhosis classification coccidioides coccidioidomycosis comparison
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Skin involvement, Kidney ... non-essential drug/HDS treatments ... for alternative causes ... #DrugInduced #Liver ... #Injury #Diagnosis
ILD of Known Cause - Differential Diagnosis Exposure: • Occupational: Asbestosis, Silicosis, Hypersensitivity, Pneumonitis • Treatment Related:
ILD of Known Cause ... - Differential Diagnosis ... Occupational: Asbestosis, Silicosis ... Pneumonitis • Treatment ... lung #disease #pulmonary
Drug Induced Kidney Injury • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy • Osmotic
Drug Induced Kidney ... CNI, ACEI/ARB, IL ... @kdjhaveri #DrugInduced ... #differential #diagnosis ... #algorithm #nephrology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
months without treatment ... Circulation Failure Kidney ... Drug-Induced Liver Injury ... (DILI) Viral Hepatitis ... gastroenterology #management #diagnosis
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
myalgia, serositis, Kidney ... Prognosis: Usually mild ... life-threatening • Treatment ... Lupusreference #druginduced ... #rheumatology #diagnosis
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
- Differential Diagnosis ... Management Summary Causes ... nephrotoxicity to kidney ... #Management #causes ... #treatment #nephrology
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
myalgia, serositis, Kidney ... Prognosis: Usually mild ... Discontinuation of causal ... Lupusreference #DrugInduced ... #diagnosis #treatment
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
disequilibrium syndrome • Diagnosis ... Torsemide) • Acute pulmonary ... stones caused by ... Tolvaptan) • Treatment ... Excretion #Diuresis #Nephrology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
the critically ill ... liver or renal injury ... perfusion - shock->treatments ... before beginning treatment ... output - Acute pulmonary
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
cytotoxic lung injury ... starting amiodarone treatment ... Exclude other causes ... Exclusion of other ILDs ... macrophages Treatment
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