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diagnosis hematology differential rheumatology causes leukemia oncology workup activation chronic cll disorders extravascular hemolysis hemolytic intravascular lymphocytic macrophage management mas
Causes of Thrombocytopenia - Differential Diagnosis Framework Decreased Production: - Drugs (chemo, yang, sulfa, acetaminophen, NSAIDs, quinine,
Causes of Thrombocytopenia ... Differential Diagnosis Framework ... folate def - Bone ... - Autoimmune: SLE ... #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Differential Diagnosis Framework ... : • Vascular occlusion ... Drug induced - Bone ... - Hemolytic anemia ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Microangiopathic hemolytic anemia ... microangiopathy: Thrombotic thrombocytopenic ... usually IgG) (e.g. lupus ... #anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Causes of Thrombocytopenia ... test, ANA (e.g., SLE ... changes), high MCV anemia ... candidate) - Bone ... Causes #Workup #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
disease • Systemic lupus ... SJIA], systemic lupus ... erythematosus [SLE ... with leukopenia, anemia ... , and thrombocytopenia
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or on bone ... - infiltrates (anemia ... , thrombocytopenia ... lymphocytic lymphoma (SLL ... #Leukemia #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... • Neutropenia, anemia ... , thrombocytopenia ... Warm AIHA • Bone ... workup #oncology #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Differential Diagnosis Framework ... such as systemic lupus ... reactions, and vaso-occlusive ... vasculitis, and SLE ... #rheumatology #classification
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