11 results
Dermatological semiology of Cutaneous Vasculitis 

Clinicopathologic correlations
 • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... the context of cutaneous ... disease (10%) : SLE ... #dermatology #semiology ... pathology #lesions #differential
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... : • Vascular occlusion ... Drug induced - Bone ... Associated - SLE ... #nonpalpable #dermatology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Disease Vaso-occlusive ... dz difficult to see ... • Differentiate ... #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
tract, and often causes ... such as systemic lupus ... reactions, and vaso-occlusive ... , and SLE) • Urinalysis ... #rheumatology #classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... : • Acute cutaneous ... permanent alopecia Differential ... Vasculitis: •
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• They can cause ... Cryoglobulins Cause ... Henoch-Schönlein purpura) • Cutaneous ... (e.g. systemic lupus ... diagnosis #types #classification
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... diseases, such as SLE ... reactions, and vaso-occlusive ... tract, and often causes
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
mutations - BMPR2 (bone ... Pulmonary veno-occlusive ... neurofibromatosis, vasculitis ... #Diagnosis #Differential ... #Causes
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
gangrenosum • Cutaneous ... Autoimmunity: • -MM/WM: Vasculitis ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
: infections (cutaneous ... of necrotizing vasculitis ... • This one is ... comparison #table #differential ... #diagnosis #dermatology