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hematology differential causes hyperkalemia potassium anesthesia anesthesiology checklist intraoperative laboratory nephrology algorithm classification disease hemolytic leukemia product reactions rheumatology testing
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... in peripheral blood ... High in acute blood ... loss, hemolysis ... #Workup #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
- infiltrates (anemia ... lymphocytic lymphoma (SLL ... Lymphocytic Lymphoma (SLL ... /SLL into a significantly ... #Oncology #Diagnosis
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential Diagnosis ... Consider sickle cell ... genotypes): SS, SC, SE ... #workup #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... spherocytosis, Hemolytic ... • Burr cells - Renal ... Morphology #Atlas #key #diagnosis ... #differential #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Diagnosis: • hemolytic ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... • Symptoms: High ... #anemia #hematology
Causes of False Elevation and Reduction in HbA1c == False Elevation == Decreased RBC turnover • Iron, B-12,
High Glucose ... turnover • Acute blood ... loss • Hemolytic ... anemia • Splenomegaly ... Increase #Decrease #Diagnosis
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Differential Diagnosis ... phlebotomy High ... Crush injury • Blood ... insufficiency/Failure • SLE ... Blood transfusion
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia ... #workup #oncology ... #hematology
Elevated Lactate Dehydrogenase (LDH) - Differential Diagnosis Framework LDH is a cytoplasmic enzyme present in tissues throughout
- Differential Diagnosis ... • Present in high ... deficiency of red blood ... anemia, PNH, immune ... #differential #diagnosis
Hyperkalemia - Differential Diagnosis Framework PseudoHyperkalemia: • Lab error • Traumatic venipuncture • Hemolysis, thrombocytosis, leukocytosis •
- Differential Diagnosis ... phlebotomy High ... Crush injury • Blood ... insufficiency/Failure • SLE ... Blood transfusion
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