11 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Syndrome (SS), ... (SLE), Systemic ... (SLE), Systemic ... Arthritis, Sjögren Syndrome ... Drug-Induced, Inflammatory
Joint Disorders - Differential Diagnosis Algorithm
Monoarthritis
 • Septic
 • Crystalline
     - Gout
arthritis - (Reiter’s syndrome ... psoriasis (7-30%) • Inflammatory ... Lupus - with Systemic ... Lupus Erythematosus ... (SLE), should have
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... photosensitivity, inflammatory ... Female • Peaks 3rd ... Skin Disease Classification ... #Systemic #Lupus
Inflammatory Joint Pain - Differential Diagnosis Algorithm 
Monoarticular
 • Gout (Podagra, Tophi)
 • Pseudogout
 • Early
bite, Migratory red ... Arthritis • Systemic ... Lupus Erythematosus ... Sicca) Syndrome ... #JointPain #MSK
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
background of a highly inflammatory ... release of pro-inflammatory ... lupus erythematosus ... lupus erythematosus ... [SLE], AOSD) •
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
Allergen-specific lgE antibodies ... - Red blood cell ... activation provides inflammatory ... lupus erythematosus ... Hypersensitivity #Types #Classification
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
(GBS), systemic ... lupus erythematosus ... (SLE), polymyositis ... (LEMS), systemic ... myopathy (IMNM) → Antibodies
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Knee Effusion Red ... Infection - Systemic ... Candidiasis Inflammatory ... arthritis - SLE ... differential #diagnosis #msk
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
: - Ocular inflammatory ... lupus erythematosus ... C-ANCA) pattern: antibodies ... vasculitis, and SLE ... #rheumatology #classification
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... hypofunction • Antibodies ... Central nervous system ... phenomenon (16%) MSK ... Biologic: 2nd or 3rd