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differential management albumin apml ascites causes chronic differentiation fatigue gradient hepatology infections infectiousdiseases leukostasis lysis mycobacteria nontuberculous ntm oncology rheumatology
Diagnosis of ascites according to the serum ascites albumin gradient (SAAG) SAAG ≥ 1.1: - Ascitic protein
Diagnosis of ascites ... , Massive liver ... , IVC obstruction ... albumin #gradient #hepatology ... #algorithm
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... - pulmonary opacities ... • Steroids: IV ... unless severe APLS ... #management #hematology
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Algorithm Endocrine ... Renal Failure • Liver ... Neoplastic / Hematologic ... Chronic Obstructive Pulmonary ... Chronic Fatigue Syndrome
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... - 80% have fever ... - ACS, AKI, ... #TLS #diagnosis ... #management #hematology
Nontuberculous Mycobacteria (NTM) Infections Mycobacterial species other than those belonging to the Mycobacterium tuberculosis complex and
Lady Windermere Syndrome ... : • Syndrome of ... Classification grp IV ... Hematologic malignancy ... Diagnosis Of NTM
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Diagnosis: • Dry ... Disease: • 10%-15% Pulmonary ... risk PE, Pulmonary ... vasculitis: 10%-16% Liver ... Nephrogenic DI Hematologic
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