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diagnosis differential rheumatology behcet cell cryofibrinogenemia disease gammopathy management mgus paraproteinemias plasmacytoma significance signs solitary symptoms workup
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis Neurologic-Centered: (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... capillary leak syndrome ... • Schnitzler syndrome ... Differential #Diagnosis #hematology ... #oncology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt+, ↑thrombosis ... Hyperviscosity (Thrombosis ... beds-renal, retinal, DVT ... Paraproteinemias #Hematology ... #Diagnosis #Oncology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
association • M > F Clinical ... Venous disease (SVC ... , dural sinus thrombosis ... (Clinical Dx). ... refractory disease : monoclonal
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
necrosis) - Thrombosis ... (Thrombotic vasculopathy ... Biopsy: Typical pathologic ... Antiphospholipid syndrome ... #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
plasmacytoma) Clinical ... tissue composed of monoclonal ... IFE, FLC assay Pathology ... #Plasmacytoma #Oncology ... Diagnosis #Workup #Hematology
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