14 results
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Approach to Thrombotic ... and Management Algorithm ... TMA: Unexplained thrombocytopenia ... Reticulocytes, smear ... #hematology
Approach to suspected Heparin-Induced Thrombocytopenia (HIT)

 • Suspected HIT Algorithm
 • "4 T's" clinical probability score:
Suspected HIT Algorithm ... • "4 T's" clinical ... - Thrombosis ... #HIT #hematology ... diagnosis #4Ts #algorithm
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
) - Monoclonal ... Viral Infection Clinical ... IgM) • Blood smear ... malignancies -> CLL ... hemolytic #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
syndrome - Thrombotic ... thrombocytopenic ... ) (e.g. lupus, CLL ... (e.g. primary cold ... differential #diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
practices that could ... peripheral blood smear ... not required in all ... dysplasia on the smear ... Causes #Workup #hematology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook

Presentation: 
 • Plts ↓50% (nadir
5-10d, venous (DVT ... Diagnosis: • Clinical ... Management: • D/c all ... non-heparin A/C if clinical ... Management #Treatment #Hematology
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
• Peripheral smear ... immunophenotype Clinical ... with anemia or thrombocytopenia ... fludarabine) 3) Monoclonal ... Leukemia #oncology #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... anemia due to cold ... Hyperviscosity (Thrombosis ... beds-renal, retinal, DVT ... Paraproteinemias #Hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... phenomenon CLL ... • Peripheral smear ... Neutropenia, anemia, thrombocytopenia ... workup #oncology #hematology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
organ damage Clinical ... • Peripheral smear ... - bleeding or thrombosis ... presence of large thrombosis ... treatment #management #hematology