6043 results
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism
AST and ALT:
 • AST: liver
Liver Chemistry ... phosphatase: • Synthesis ... due to increased synthesis ... clearance - AP synthesis ... Pathophysiology #Diagnosis
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... salts augment synthesis ... ALP - Due to synthesis ... source - Tests of synthetic ... #differential #diagnosis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Liver Chemistries ... Identify Acute Liver ... salts augment synthesis ... ALP - Due to synthesis ... #chemistry #diagnosis
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Findings in Hepatic / Liver ... Decreased albumin synthesis ... fold with acute liver ... has exhausted liver ... Hepatology #Laboratory #Diagnosis
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Decreased factor synthesis ... • Reduced liver ... synthesis (impaired ... Prolonged #Causes #diagnosis
Abnormal liver function tests algorithm.
 This figure details the initial response to abnormal liver blood tests.
Abnormal liver function ... blood tests, synthetic ... sought to support a diagnosis ... Areas of diagnostic ... #Differential #Diagnosis
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
Early liver disease ... Decreased factor synthesis ... Reduced liver synthesis ... Prolonged #Causes #diagnosis
Portal Hypertension - Differential Diagnosis
Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... Preserved hepatic synthetic ... sarcoidosis) • Liver ... metastasis • Fatty liver ... #Differential #Diagnosis
5-Oxoprolinuria
What is it:
 • Aka pyroglutamic acidosis, Intermediate in γ-glutamyl cycle
 • Amino acid transport and
and glutathione synthesis ... deficiency) • Liver ... flucloxacillin, vigabatrin Diagnosis ... Oxoprolinuria #diagnosis
Functions of the Liver

Storage 
Degradation 
Metabolism 
Synthesis 

#Pathophysiology #Functions #Liver #Hepatology #Synthesis #Storage #Metabolism
Functions of the Liver ... Metabolism Synthesis ... Pathophysiology #Functions #Liver ... #Hepatology #Synthesis