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diagnosis management infections histoplasmosis infectiousdiseases opportunistic aids capsulatum coagulation differential distribution fungal hematology hiv hivaids idsa intravascular mycoses neurology pharmacology
Histoplasmosis - Histoplasma capsulatum Found in Spelunkers. Caves. Bat and Bird droppings Distribution: Mississippi and Ohio River
Caves. ... River Valleys Clinical ... asymptomatic • Disseminated ... immunocompromised • Primary ... infection: TB-like Treatment
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... organ damage Clinical ... Thromboembolism (7%) • CNS ... : • Treat primary ... #hematology
CNS Infection in HIV / AIDS - Differential Diagnosis Framework Principles of HIV-Associated CNS Opportunistic Infections: •
encephalitis, and primary ... should be based on clinical ... Antimicrobial treatment ... Demyelinating disease caused ... Syphilis • Aspergillosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... • 8%-27% for CNS ... • Nephrogenic DI ... Adenocarcinoma Treatment
IDSA Recommendations for Preventing and Treating Histoplasma Capsulatum Infections in HIV-AIDS Indications for Initiating Primary Prophylaxis: •
Preventing and Treating Histoplasma ... histoplasmosis (>10 cases ... Severe to Severe Disseminated ... weeks or until clinically ... IDSA #Prevention #Treatment
Mycoses HISTOPLASMOSIS • Inhalation of conidia → Yeast → travel to lymph nodes → spread in body • Bird
Diagnosis: • Histoplasma ... has five major clinical ... fungal stain of clinical ... especially the CNS ... MC: CNS CSF: •
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