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management hematology hemophagocytic hlh lymphohistiocytosis arteritis capillary disease encephalopathy gca giantcell hemeonc leak neurology polychondritis posterior pres relapsing reversible signs
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Clarkson’s Disease ... Relapsing-remitting course +++ Clinical ... month at least 1 year ... #diagnosis #management ... #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
accumulation of clinical ... B-LNH), solid cancers ... Treatment: • ... Nicolas Taar ... #summary #rheumatology
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Autoimmune disease, Cancer ... epilepticus Treatment ... the underlying cause ... • Treatment of ... until cause identified
Syphilis - Clinical Manifestations and Treatment 1) Primary Syphilis • Direct lesion contact during sex is responsible
Syphilis - Clinical ... responsible for most cases ... Albuminuria, nephrotic syndrome ... Late latent >1 year ... Syphilis #stages #diagnosis
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
Diagnosis = clinical ... in literature (NEJM ... (Cornelia NEJM ... Treatment of GCA ... them, but urgent rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Adenocarcinoma Treatment ... Symptomatic: artificial tears ... #Rheumatology #
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
the most common clinical ... : • Clinical tests ... affected tissue Treatment ... Polychondritis #rheumatology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
HLH is a critical ... caused by uncontrolled ... it is often a cancer ... Clinical Presentation ... #Management #Hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
current treatment ... algorithm 2018. ... median age at diagnosis ... importance of clinical ... #algorithm #hematology
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