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differential arthritis management signs joint pain rheumatoid approach autoinflammatory behcet classification conditions cryofibrinogenemia disease e1 extrarticular polychondritis relapsing sjogrens somatic
Rheumatoid Arthritis Summary MCP and PIP Involvement, Spares DIP, Carpal Tunnel, Sicca Syndrome, Epi/Scleritis, Heart Disease, Rheumatoid
Tunnel, Sicca Syndrome ... Disease, Rheumatoid Vasculitis ... (RA + Neutropenia ... #diagnosis #rheumatology ... #signs #symptoms
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
recurrent fevers, vasculitis ... • Hematologic ... (MDS) Most met criteria ... myeloid cells NEJM ... Autoinflammatory #Somatic #rheumatology
Extra-articular and Other Conditions Associated with Joint Pain Eyes • Iritis or uveitis - Spondyloarthropathies, Sarcoidosis,
• Scleritis - RA ... Lyme disease, Vasculitis ... Inflammation of ear ... #differential #diagnosis ... #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... • Cogan Syndrome ... well as inner ear ... Presentation - Systemic Symptoms ... #rheumatology #
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
, small-vessel vasculitis ... meningitis), MCC CNS symptoms ... Giant retinal tears ... #signs #symptoms ... #rheumatology #
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... Presentation: Systemic Symptoms ... • Progressive symptoms ... #Rheumatology
Rheumatoid Arthritis - Signs and Symptoms • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans • Pulmonary:
Arthritis - Signs and Symptoms ... Vascular: Rheumatoid vasculitis ... Thrombocytosis, Felty's syndrome ... Rheumatoid #Arthritis #RA ... #diagnosis #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Cryofibrinogenemia Symptoms ... malignancies, vasculitis ... Antiphospholipid syndrome ... #rheumatology # ... hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA ... Nephrogenic DI Hematologic ... phenomenon (16%) MSK ... Symptomatic: artificial tears ... #Rheumatology #
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
or nerve root Symptoms ... rheumatoid arthritis (RA ... e.g., meniscal tears ... #Joint #Pain #MSK ... #rheumatology #
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