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diagnosis rheumatology differential management hepatology liver abnormal ana antibodies antinuclear chemistry classification enzymes interpretation pathophysiology patterns polychondritis primary relapsing rvalue
Primary Sjogren’s Syndrome: Pathogenesis and Clinical Findings • Primary Sjögren's is a solitary process whereas secondary Sjögren's
s Syndrome: Pathogenesis ... primary biliary cirrhosis ... (SLE) Signs / Symptoms ... - Decreased tear ... Diagnosis #Signs #Symptoms
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
context of other symptoms ... erythematosus (SLE), Sjogren's ... Syndrome (SS), ... Syndrome, Myositis ... Primary Biliary Cirrhosis
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... primary biliary cirrhosis ... Nephrogenic DI Hematologic ... Symptomatic: artificial tears ... #Syndrome #Rheumatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... Elevation of ALP • Near ... hepatitis: < 1 • Cirrhosis ... • Gilbert's syndrome ... transaminitis #LFTs
Abnormal liver function tests algorithm. This figure details the initial response to abnormal liver blood tests.
function tests algorithm ... suspicious clinical symptoms ... presence of metabolic syndrome ... #LFTs #Abnormal ... #Algorithm #Hepatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
• Cogan Syndrome ... well as inner ear ... Presentation - Systemic Symptoms ... Tests: • CBC • LFT ... differential #diagnosis #rheumatology
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
erythematosus (SLE), Sjögren ... (SFTS) - POEMS ... - Hepatic cirrhosis ... and the systemic symptoms ... diagnosis #management #rheumatology
Relapsing Polychondritis What is it? Recurrent inflammation of the cartilage in the body (Autoimmune disorder) Who? • Most frequently: 40
ethnicities Symptoms ... + Nonspecific symptoms ... Eyes • Inner ear ... Most common • Sjogren ... Polychondritis #rheumatology
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