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diagnosis hematology antibody autoimmune classification cold crisis disease extravascular hemolysis hodgkins intravascular lymphoma nephrology oncology renal scleroderma src thromboticthrombocytopenicpurpura treatment
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
C3d • Blood smear ... : Differential → ... 2) LOOK FOR a cause ... #management #treatment ... #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
• Symptoms of anemia ... anemia • Cold ... IgM) • Blood smear ... younger pts) Differential ... #anemia #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... . primary cold agglutin ... #differential # ... #anemia
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
result in severe anemia ... Peripheral blood smear ... anemia Indirect ... WBC count and differential ... Diagnosis #Workup #Hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
Weight loss • Anemia ... nodosum • Immune hemolytic ... anemia • Pain ... Immunohistochemical studies (to differentiate ... #oncology #management
Scleroderma Renal Crisis (SRC) Clinical Presentation of Scleroderma Renal Crisis: 1) Acute kidney injury 2) Abrupt onset of hypertension 3)
Crisis: 1) Acute kidney ... microangiopathic hemolytic ... anemia (MAHA) ... • Refractory cases ... Renal #Crisis #rheumatology
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