6 results
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Diagnosis: • hemolytic ... IgM) • Blood smear ... younger pts) Differential ... #disease #hemolytic ... #anemia #hematology
Warm Antibody Autoimmune Hemolytic Anemia 
1) DIAGNOSE AIHA
 • Anemia: macrocytic > normocytic, ↑ reticulocytes
 •
Antibody Autoimmune Hemolytic ... C3d • Blood smear ... : Differential → ... 2) LOOK FOR a cause ... management #treatment #rheumatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... . primary cold agglutin ... Extravascular #Causes ... #differential # ... diagnosis #hematology
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura

Activity of von Willebrand factor-cleaving protease activity - A
decrease in most cases ... Peripheral blood smear ... WBC count and differential ... hematuria (without casts ... Diagnosis #Workup #Hematology
Waterborne Infections - Differential Diagnosis Framework

Infections that can be acquired from fresh water, brackish water, sea
Waterborne Infections - Differential ... toxin-producing) and Hemolytic ... Liver failure - Kidney ... - And, in rare cases ... #Diagnosis #InfectiousDiseases
Fever After International Travel

Infectious Disease:
• Endemic in either the destination or home region

Viral Syndromes:
Arboviral infections, a
infections, a common cause ... No hemolytic anemia ... chest film; blood-smear ... Fever #Travel #Differential ... #Diagnosis #InfectiousDiseases