53 results
Stiff Person Syndrome (SPS) - Diagnosis and Management Summary

Epidemiology:
 • Prevalence: 1-2 cases per million -
Diagnosis and Management ... Prevalence: 1-2 cases ... Person Syndrome Pathophysiology ... autoantibodies - TPO, TTG ... SPS #Diagnosis #Management
Hypophosphatemia and Hypoxia - Pathophysiology

↓ Phosphate leads to ↓ red cell 2,3-DPG and a  reduction
and Hypoxia - Pathophysiology ... reduction in ATP ... pathway away from ATP ... Phosphate is a cause ... respiratory #hypoxia #pathophysiology
Dropped Foot Gait - Paralysis of Dorsal Flexion of the Foot.
When trying to walk the tip
trying to walk the tip ... avoid this, he raises ... peroneal nerve, which causes ... the dorsiflexor muscles ... flexion of the thigh
Cardiac Myocyte Contractile cycle
 - Ca2+ binds to TnC → TnI is inhibited → conformational change
then binds a new ATP ... progressively shorten the muscle ... remains sufficiently high ... there is enough ATP ... #Pathophysiology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
Heat Cramps: • Muscle ... Collapse: • Pathophysiology ... High body temperatures ... Hyperventilation, Dizziness, Nausea ... differential #diagnosis #causes
Freiberg Infraction - MSK Radiology
Imaging Findings:
 • Sclerosis of the 2nd MT head with flattening of
Freiberg Infraction - MSK ... Widening of the MTP ... Case description ... hallux valgus, and high-heels ... Radiology #diagnosis #msk
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... • TMA’s (HUS/TTP ... Schistocytes - MAHA: TTP ... Treat primary cause ... #treatment #management
Scurvy (Vitamin C Deficiency) - Diagnosis and Management

Vitamin C is required for hydroxylation of proline residues
Diagnosis and Management ... nonimmune hemolysis MSK ... • Weakness • Muscle ... , or any other cause ... periodontitis • ITP
Constrictive Pericarditis on POCUS Echocardiogram - Apical 3-Chamber View

Young Lupus patient admitted to hospital new onset
Pericarditis on POCUS ... could pinpoint the cause ... BP high-no evidence ... Had diagnostic tap-fever ... Pericarditis #CP #POCUS
Guillain-Barre Syndrome - Summary

Acute AIDP that presents with rapidly progressive flaccid weakness

Epidemiology:
 • 1-2 cases/100,000 per
Epidemiology: • 1-2 cases ... Guillain-Barre Pathophysiology ... Fairly symmetric muscle ... • Respiratory Muscle ... Syndrome #diagnosis #management