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Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Gitelman Syndrome ... • Gitelman's syndrome ... distal convoluted tubule ... , Renal tubular ... diagnosis #nephrology #management
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Framework and Management ... - Compartment syndrome ... formation: Renal tubular ... nephrotoxicity to kidney tubular ... Differential #Diagnosis #Management
Rhabdomyolysis - Differential Diagnosis and Management Summary Trauma: • Immobilization, Crush iniury, Compartment syndrome, Electrical injury Exertional: •
Diagnosis and Management ... iniury, Compartment syndrome ... Neuroleptic malignant syndrome ... formation: Renal tubular ... Differential #Diagnosis #Management
Localization of Renal Tubular Defects Fanconi Syndrome: Proximal tubule Bartter Syndrome: Thick ascending loop of Henle Gitelman Syndrome: Distal
Localization of Renal Tubular ... : Proximal tubule ... Bartter Syndrome ... Distal convoluted tubule ... : Collecting tubule
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Sjogren's Syndrome ... SLE • Mikulicz syndrome ... (Type I) renal tubular ... #Sjogrens #Syndrome ... Rheumatology #Diagnosis #Management
Compartment Syndrome Pearls A vicious cycle of increased pressure within a facial compartment leading to compression of
Compartment Syndrome ... Myoglobinuria & Tubular ... #Compartment #Syndrome ... #diagnosis #management
Proximal Renal Tubular Acidosis (RTA) Ttype 2 Overview HCO3 reabsorptive failure Lowering of threshold for HCO3 absorption in
Proximal Renal Tubular ... absorption in proximal tubule ... Proximal #Diagnosis #Management
Inherited Defects in Kidney Tubule Epithelial Cells Renal glucosuria - Na+-dependent glucose cotransporter Cystinuria - Amino acid transporter Bartter
Defects in Kidney Tubule ... limb Gitelman syndrome ... distal convoluted tubule ... Liddle syndrome ... Distal renal tubular
Nephron Physiology - Proximal Convoluted Tubule - Thick Ascending Limb - Distal Convoluted Tubule - Ion
Proximal Convoluted Tubule ... Distal Convoluted Tubule ... in Collecting Tubule ... in Collecting Tubule ... Nephrology #Renal #Tubules
Renal Tubular Acidosis (RTA) Diagnosis and Management • Distal (type 1) RTA • Proximal (type 2)
Renal Tubular Acidosis ... Diagnosis and Management ... #rta #Renal #Tubular ... Acidosis #Diagnosis #Management
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