vWF clinical - GrepMed

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Von Willebrand Disease Classification
Type 1 (Accounts for ~3/4 of cases):
• Defect: Quantitative defect (i.e. not

i.e. not enough VWF ... dysfunctional VWF ... total absence of vWF ... Bleeding: Severe (Clinically

Bleeding manifestations
Petechiae are small, flat, red, discrete areas of skin bleeding that are typically <2

Diagnosis VWF ... (Quantity of VWF ... considered to be low) VWF ... of this plasma VWF ... (differentiate VWD

Coagulation cascade and anticoagulants

Satyendra Dhar MD, @DharSaty

#coagulation #coumadin #heparin #warfarin #apaxiban #pradaxa #xarelto #DOAC #vWF

xarelto #DOAC #vWF

Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
• Defective aggregation to all agonists except ristocetin
• Normal platelet,

also be seen in vWD ... differentiate vWD ... BS by measuring vWF

Acquired von Willebrand Syndrome - Diagnosis and Management
• Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,

Autoantibodies to vWF ... Autoimmune disease • vWF

Approach to Von Willebrand disease (VWD)

By Matthew Ho, MD PhD @MatthewHoMD

#VWD #Von #Willebrand #VonWillebrand #disease #hematology

Willebrand disease (VWD ... MatthewHoMD #VWD

Inherited Qualitative Platelet Defects
Bernard-Soulier Syndrome
• Defect of adhesion due to a lack of GP Ib/IX/V

of GP Ib/IX/V [vWF ... α-granules (contains vWF

2021 ACR/VF Guidelines for Management of Giant Cell Arteritis (GCA)

#GiantCell #Arteritis #GCA #ACR2021 #Management #rheumatology #algorithm

2021 ACR/VF Guidelines

Ventricular Fibrillation on Echocardiogram (A4C)
Rare glimpse of echocardiogram just at the onset of VF, no organized

at the onset of VF ... #Fibrillation #clinical

Ventricular Fibrillation caught during Fluoroscopy

Have you seen heart fibrillating due to VF during CAG?! Thanks to

fibrillating due to VF ... Fibrillation #Angiogram #clinical

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