10 results
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
Macrophage Activation ... lupus erythematosus ... lupus erythematosus ... : Evidence of macrophage ... Syndrome #Diagnosis #Management
Systemic Lupus Erythematosus - Summary
Antinuclear (ANA) - 95% - Initial screening test
Anti-dsDNA - 50%
 • Associated
Systemic Lupus Erythematosus ... monitor disease activity ... • MCTD (SLE/systemic ... #Lupus #Erythematosus ... #rheumatology #management
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... arthritis, and systemic ... lupus erythematosus ... cytokines, which activate ... macrophages and
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... polyclinic or patchy papulosquamous ... extremity edema, active ... Neuropsychiatric systemic ... CRP normal, ESR active
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
by the alveolar macrophages ... IFN-γ-activated macrophages ... aggregation of macrophages ... • Skeletal system ... TB #Diagnosis #Management
Tuberculosis Overview

10 million new M. tuberculosis infections/year
Facultative intracellular rod-shaped bacteria
Multidrug-resistant tuberculosis (MDR-TB) accounts for 4.6% of
by the alveolar macrophages ... IFN-γ-activated macrophages ... aggregation of macrophages ... • Skeletal system ... TB #Diagnosis #Management
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
tissues where they activate ... glomerulonephritis, Systemic ... lupus erythematosus ... Antigen-presenting cells activate ... T-cells recruit macrophages
Holistic Management of Systemic Lupus
 • Lifestyle interventions: Smoking cessation, Photoprotection, Therapeutic adherence, Anxiety/depression/fatigue, Fibromyagia/pain management,
Holistic Management ... of Systemic Lupus ... , Physical activity ... holistic #SLE #Systemic ... #Lupus #Erythematosus
Sarcoidosis - Diagnosis and Management Summary
Epidemiology
1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Diagnosis and Management ... increased B-cell activity ... the lymphatic system ... dysregulation: activated macrophages ... skin (16-32%): lupus
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
syndrome (GBS), systemic ... lupus erythematosus ... syndrome (LEMS), systemic ... increased spontaneous activity ... myopathy #diagnosis #management