Adrenoceptor Actions α1 • Vascular smooth muscle - Contraction • Genitourinary smooth muscle - Contraction • Intestinal smooth muscle - Relaxation • Heart - ↑ Inotropy and excitability • Liver - Gycogenolysis and gluconeogenesis α2 • Pancreatic ß-cells - ↓ Insulin secretion • Platelets - Aggregation • Nerve - ↓ Norepinephrine release • Vascular smooth muscle - Contraction ß1 • Heart - ↑ Chronotropy and inotropy • Heart - ↑ AV node conduction velocity • Renal juxtaglomerular cells - ↑ Renin secretion ß2 • Smooth muscle - Relaxation • Liver - Glycogenolysis and gluconeogenesis • Skeletal muscle - Glycogenolysis and K+ uptake ß3 • Adipose - Lipolysis #Adrenoceptor #adrenergic #receptors #actions #pharmacology #pathophysiology #comparison #table
