Pathophysiological mechanisms of diastolic heart failure HFpEF and possible therapeutic interventions. Hypertension → Overload Diabetes → Oxidative stress, RAGE activation CAD Microvessels → Disseminated Ischemia Obesity → Overload → Cardiomyocyte hypertrophy, Cardiomyocyte stiffening (titin), Interstitial and perivascular fibrosis → Diastolic relaxation defect, Reduced regulatory reserve → Pulmonary congestion, Peripheral congestion, Decreased output #diastolic #heartfailure #dchf #hfpef #pathophysiology
