Antiobesity Drugs and Their Effects Orlistat • GI Lipase inhibitor • Reduces lipid absorption • Toxicity: Decreased absorption of fat-soluble vitamins, flatulence, fecal Liraglutide • GLP-1 agonist • Decreases appetite incontinence • Toxicity: Nausea, vomiting, pancreatitis Lorcaserin • 5-HT2c agonist • Decreases appetite • Toxicity: Headache, nausea, dry mouth, dizziness, constipation Naltrexone/bupropion • Opioid antagonist + antidepressant • Unknown • Toxicity: Headache, nausea, dizziness, constipation Phentermine • Sympathomimetic • Norepinephrine release in CNS • Toxicity: Increased BR HR; arrhythmias, insomnia, anxiety Phentermine/topiramate • Sympathomimetic + antiseizure agent • Norepinephrine release plus unknown mechanism • Toxicity: Insomnia, dizziness, nausea, paresthesia, dysgeusia #Antiobesity #Drugs #medications #pharmacology #management
