DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1 and GIP. Examples: • Sitagliptin (Januvia) - Once/day tablet • Saxagliptin (Onglyza) - Once/day tablet • Linagliptin (Tradjenta) - Once/day tablet Major Advantages: None specific Contraindications: • Recommended to avoid combination therapy with GLP-I receptor agonist • Personal history of pancreatitis • Saxagliptin is contraindicated in heart failure Common Side Effects and Toxicities: • Joint pains, myalgias • Association with pancreatitis (though not definitively cause/effect) • Saxagliptin is associated with t risk of heart failure hospitalizations - Dr. Eric Strong @DrEricStrong - Strong Medicine https://www.youtube.com/c/EricsMedi #DPP4 #Inhibitors #Pharmacology #Summary #DM2 #diabetes #endocrinology
