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diabetes pharmacology endocrinology dm2 management medications comparison oral dosing inhibitors table treatment agonists allergy angioedema antidiabeticagents bradykinin chart ckd classification
DPP-4 Inhibitors - Pharmacology Summary Mechanisms of Action: Inhibits DPP-4 (dipeptidyl peptidase 4), which normally inactivates GLP-1
DPP-4 Inhibitors ... Action: Inhibits DPP ... EricsMedicalLectures/featured #DPP4
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
Metformin + DPP4 ... dapagliflozin) Dpp4
DPP4 Inhibitors - Normal and Renal Dosing Increase Incretins (GLP-I & GIP) -> Stimulates Insulin, Inhibits Glucagon
DPP4 Inhibitors ... linagliptin) 5 mg DPP4 ... lower dose of a DPP4 ... /ambcarerx #DPP4
Mechanism of Action for Common Diabetes Medications • SGLT2i (Dapagliflozin) • TZD (Pioglitazone) • Biguanides (Metformin)
Receptor Agonists • DPP4i
Oral Hypoglycemics in Diabetes Management 1 INSULIN SENSITIZER • TZD -
(Adlyxin) • DPP ... by inhibiting DPP
Diabetes Medications Summary Table Insulin Lifestyle modifications Metformin Sulfonylureas GLP-1 receptor agonists - ↓ major adverse CV events TZDs DPP-4 inhibitors SGLT2 inhibitors -
events TZDs DPP
Effects on body weight of various classes of type-2 diabetes medications. - Metformin - Weight Loss
Weight Loss +++ - DPP
Patient factors influencing the selection Of glucose-lowering drugs Other than SGLT2i and metformin in T2D and
kidney disease, DPP4i
#diabetes #T2DM #antidiabeticagents #oraldiabeticagents FIGURE 9.1 Glucose-lowering medication in type 2 diabetes: overall approach. For appropriate context,
outcomes trials; DPP
Bradykinin-mediated Angioedema Clinical features: Submucosal oedema (face, extremity, genitalia), Laryngeal dyspnea (25% of deaths), Recurrent attacks of
people, concomitant DPP4
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