Cephalosporin Coverage First-generation cephalosporins: - Gram (+) cocci: Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, Anaerobic streptococci - Gram (-) rods: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis Second-generation cephalosporins: - Gram (+) cocci: Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus pyogenes, - Anaerobic streptococci - Gram (-) cocci: Neisseria gonorrhoeae - Gram (-) rods: Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis - Anaerobic organisms* * Third-generation cephalosporins: Gram (+) cocci: Streptococcus pneumoniae, Streptococcus pyogenes, Anaerobic streptococci - Gram (-) cocci, Neisseria gonorrhoeae - Gram (-) rods: Enterobacter aerogenes, Escherichia coli, Haemophilus influenzae, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens #Cephalosporin #Coverage #antimicrobial #pharmacology
