Duke's Criteria for Infective Endocarditis
Definite IE - Pathologic Criteria:
• Pathologic lesions - vegetation or intracardiac abscess demonstrating active endocarditis on histology OR
• Microorganism - demonstrated by culture or histology of a vegetation or intracardiac abscess
Definite IE - Clinical Criteria:
• 2 major clinical criteria OR
• 1 major and 3 minor clinical criteria OR
• 5 minor criteria
Possible IE:
• Presence of 1 major and 1 minor clinical criteria OR
• Presence of 3 minor clinical criteria
Major Criteria:
• Positive blood cultures for IE
- Typical microorganisms consistent with IE from 2 separate blood cultures
- Persistently positive blood culture
- Single positive blood culture for Coxiella burnetii or phase I IgG antibody titer > 1:800
• Evidence of endocardial involvement
- Echocardiogram positive for IE
- New valvular regurgitation
Minor Criteria:
• Predisposition
• Fever
• Vascular phenomena
• Immunologic phenomena
• Micro: + bcxs that do not meet major criteria OR serologic evidence of active infection with organism consistent with IE
By Dr. Sara Dong @swinndong via Febrile [febrilepodcast.com @febrilepodcast]
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