Non-Infective Endocarditis - Pathophysiology Non-infective Endocarditis Pathophysiology: • Valves usually undamaged - Etiology poorly understood but thought to be combination of different interacting mechanisms • Circulating immune complexes + Carcinomatosis → Hypercoagulable state → Valve destruction or failure is rare Infective Endocarditis Pathophysiology: • Underlying damage to valve endothelium is common → Bacteria adhere to damaged endothelium and propagate → Vegetation forms and promotes activation of clotting cascade → Fibrin and platelet deposition over clusters of bacteria → Valve destruction and failure - Infectious Diseases Fellows Network @ID_fellows #NonInfective #Endocarditis #NBTE #Marantic #pathophysiology
