Amyloidosis Diagnosis 1) Patient presentation • Cardiac-specific signs of amyloidosis: Diastolic heart failure, Heart failure with preserved ejection fraction, Infiltrative cardiomyopathy • Noncardiac signs of amyloidosis: Nondiabetic proteinuria, Nondiabetic neuropathy, Hepatomegaly and diarrhea, Monoclonal gammopathy of undetermined significance (MGUS) neuropathy, atypical MGUS, or smoldering myeloma 2) Methods of amyloid detection • For cardiac-specific signs: technetium pyrophosphate (PYP) or methylene diphosphonate (DPD) scan - Scan results graded from 0 to 3 based on comparison of radionucleotide uptake between ribs/sternum and heart • For noncardiac signs: monoclonal immunoglobulin (Ig) screen with serum and urine immunofixation: Presence of monoclonal protein, Abnormal lg free light chain levels 3) Amyloid Detection Results #Amyloidosis #Diagnosis #cardiology
