Nonopioid Analgesic Agents Acetaminophen Aspirin NSAIDs Amitriptyline Duloxetine Gabapentin Pregabalin Lidocaine Patch Capsaicin Patch #Nonopioid #Analgesic #medications #drugs #comparison #table #pharmacology

Maximum Statin Dosing - Adjustments in CKD Atorvastatin Lovastatin Pitavastatin Pravastatin Rosuvastatin Simvastatin Fluvastatin Simvastatin/ezetimibe doi: 10.20945/2359-3997000000306 #Statin #Dosing #CKD #pharmacology

Lactic Acidosis - Classification and Differential Diagnosis Type A Lactic Acidosis: Inadequate Oxygen Delivery • Anaerobic muscular activity: Exercise, Generalized convulsions • Tissue hypoperfusion: Cardiac arrest, Regional hypoperfusion, Shock • Reduced tissue oxygen delivery: Hypoxemia, Anemia Type B Lactic Acidosis: No Evidence of Inadequate Tissue Oxygen Delivery • Associated with underlying disease: Diabetic failure, Hepatic failure, Infection, Leukemia, Lymphoma, Pancreatitis, Renal failure, Short bowel syndrome, Thiamine deficiency • Associated with drugs and toxins: Acetaminophen, Anti-retroviral drugs, Beta-agonists, Biguanides, Carbon monoxide, Cyanide, Epinephrine, Fructose, Isoniazid, Lactate-based dialysate, Metformin, Methanol, Nitroprusside infusion, Salbutamol, Salicylates, Sorbitol • Associated with inborn errors of metabolism doi: 10.1177/0885066620982585 #Lactic #Acidosis #Classification #Differential #Diagnosis #TypeA #TypeB #lactate

Statin Drug-Drug Interactions with HIV ART Medications PIs - NNRTIs - ISTIs Dose Adjustments doi: 10.20945/2359-3997000000306 #Statin #Drug #Interactions #DDIs #HIV #ART #Medications #table

Invasive Fungal Infections in AIDS - Cryptococcosis - Histoplasmosis - Coccidiodomycosis - Talaromycosis doi:10.1007/s11908-017-0592-7 #Fungal #Infections #HIVAIDS #comparison #table #mycoses

NAFLD Activity Score (NAS) 0–3 for steatosis 0–3 for inflammation 0–2 for ballooning hepatocytes NAS ≥5 is classified as definitive NASH rather than a simple fatty liver disease doi: 10.3389/fphar.2020.603926 #NAFLD #Activity #Score #NAS #diagnosis #hepatology

Adnexal Masses - Benign vs Malignant Features on Ultrasound and MRI Benign Features: B1- Unilocular B2- Presence of solid components with a largest diameter of <7 mm B3- Presence of acoustic shadows B4- Smooth multilocular tumor with a largest diameter of <100 mm B5- No blood flow (color score 1) Malignant Features: M1- Irregular solid tumor M2- Presence of ascites M3- At least 4 papillary structures M4- Irregular multilocular-solid tumor with a largest diameter of ≥100 mm M5- Very strong blood flow (color score 4) doi:10.3390/cancers12123795 #Adnexal #Masses #Ovarian #benign #malignant #ultrasound #MRI #radiology

Evans Syndrome Pharmacology Management Corticosteroids IVIg Rituximab Splenectomy Azathioprine Cyclophosphamide Cyclosporin Mycophenolate Vinka-alkaloid Plasma exchange Transfusion Anticoagulation Bone marrow stimulating agents doi:10.3390/jcm9123851 #Evans #Syndrome #Pharmacology #Management #Medications #comparison #table

Natural History of Syphilis Primary - 2-6 weeks after infection • Chancre, Regional lymphadenopathy Early Latent ≤ 1 year after infection • Asymptomatic Secondary - 1-2 months after primary syphilis • Rash, Fever, Generalized lymphadenopathy, Mucosal lesions, Alopecia, Hepatitis, Nephritis Late Latent - > 1 year after infection • Asymptomatic Early Neurosyphilis → Late Neurosyphilis Tertiary Syphilis - 2-50 years after infection • Gummatous disease (15%); Cardiovascular syphilis (10%); Ocular syphilis; Otic syphilis; Meningovascular disease, meningomyelitis, general paresis, tabes dorsalis (5%) #Syphilis #timeline #progression #diagnosis #stages

Syphilis Clinical Findings - Chancre and Characteristic Rash A: Syphilitic chancre with a clean, painless base and raised edges. B and C: Squamous plaque on the palm and sole, respectively, of a patient with syphilis. D: Gram bacteria - corkscrew-like in appearance, which is characteristic of Treponema pallidum. #Syphilis #Clinical #photo #chancre #palms #soles #rash #dermatology