Anaphylaxis Diagnostic Criteria Anaphylaxis is highly likely when any one of the following 2 criteria are fulfilled: 1. Acute onset of an illness (minutes to several hours) with simultaneous involvement of the skin, mucosal tissue, or both (eg, generalized hives, pruritus or flushing, swollen lips-tongue-uvula) AND AT LEAST ONE OF THE FOLLOWING: a. Respiratory compromise (eg, dyspnea, wheeze-bronchospasm, stridor, reduced PEF, hypoxemia) b. Reduced BP or associated symptoms of end-organ dysfunction (eg, hypotonia [collapse], syncope, incontinence) c. Severe gastrointestinal symptoms (eg, severe crampy abdominal pain, repetitive vomiting), especially after exposure to non-food allergens 2. Acute onset of hypotension or bronchospasm or laryngeal involvement after exposure to a know or highly probable allergen for that patient (minutes to several hours), even in the absence of typical skin involvement. #Anaphylaxis #diagnosis #Criteria #allergy
