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Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
/ Normochromic RBCs ... TIBC, Hypochromic RBCs ... Decreased RBC ... Thalassemia • RBC ... Disorder • RBC
Urine Microscopy and Casts - Image Atlas Key

- Squamous Epithelial Casts
- Transitional Epithelial Cells
- Renal Tubular
- Monomorphic RBCs ... - Dysmorphic RBCs ... Granular Casts - WBC ... Cast - RBC Cast
The differential diagnosis for an elevated MCHC (mean corpuscular hemoglobin concentration) includes:

Conditions with Abnormal RBCs:
 •
with Abnormal RBCs ... : • Abnormal RBC ... Xerocytosis • RBC
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Decreased WBCs
 - Decreased/NormaI
Macrocytes, Normal RBCs ... Polychromatic Macrocytes, RBC ... Spherocytes, RBC ... ) - Abnormal RBCs
Nephritic vs Nephrotic Syndrome

Step 1: If the patient has hematuria and/or proteinuria, think about nephrotic/nephritic syndromes.
Step
glomerular hematuria (RBC ... or dysmorphic RBCs
Plasmodium falciparum life cycle
1: Mosquito bite, transmission of sporozoite
2: Liver, Asexual replication. 1 sporozoite → 10-30,000
Merozoites infect RBC ... RBC ruptures releasing ... Merozoites infect other RBCs
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
red blood cells (RBCs ... serum due to the RBCs ... Smear #Microscopy #RBC
Red cell autoagglutination is the process whereby red cells clump together forming aggregates. This is seen
red blood cells (RBCs ... serum due to the RBCs ... Smear #Microscopy #RBC
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
2) External (RBC ... 3) Internal (RBC ... Smear ↑ abnormal RBCs
Anemia Diagnostic Algorithm

Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
(MCV): Average RBC ... among size of RBCs ... wide range of RBC ... reticulocytes (immature RBCs