Natural History of HIV Infection - Timeline of Progression Acute: • Viral Transmission → High VL (steady state by 6 months) • CD4 drops • Mono like illness; Sx > 14 days a/w ↑ progression to AIDS Chronic: • Stable VL, progressive decline in CD4 count • Asymptomatic, +/- fevers, sweats, weight loss, LAD +/- OIS • Effects of chronic inflammation AIDS: • CD4 < 200 or AIDS defining illness ART: • CD4 may increase x 50-150 in first year, then 50-100 each year until steady state BWH Medicine Residency @BrighamMedRes #HIV #Timeline #Progression #diagnosis #AIDS #history
