125 results
Antiphospholipid Syndrome (APS)
APS is a rare autoimmune disorder characterized by recurring blood clots resulting from antibodies
) APS is a rare ... Antiphospholipid antibodies (aPL ... 1 of the three aPLs ... diagnosed with APS ... recommended in APS
Antiphospholipid Syndrome (Hughes' Syndrome) 
Antiphospholipid syndrome - an autoimmune condition where the affected individual produces antibodies
Hughes #Syndrome #APLS
Recurrent / Breakthrough DVT During Anticoagulation

Subtherapeutic Anticoagulation
Hypercoagulable State 
 - Antithrombin deficiency 
 - Hypercoagulability ot
Behcet's disease - APLS
Differential diagnosis of schistocytes / fragmentation hemolysis:
 • Thrombotic microangiopathies (TMA)
    - TTP
• Catastrophic APLS
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Incidence: common in APL ... unless severe APLS
Causes of Purpura - Differential Diagnosis
Non-PalpabIe → Palpable
 • Thrombocytopenia (HIT, ITP/HUS), Coagulation defects (DIC, warfarin
Vasculopathy - HyperC: APLS
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Hyperviscosity, TTP, APLS ... Antiphospholipid antibodies (APLS
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytic leukemia (APL ... In addition to APL ... Rods #AuerRods #APL
Causes of Thrombocytopenia - Differential Diagnosis Algorithm
 
Decreased Megakaryopoiesis
 • Aplastic Anemia
 • Toxic Damage (e.g.
SLE • CLL • APLA
Low-dose aspirin and low-molecular-weight heparin in lupus and Antiphospholipid Syndrome (APS) pregnancy

• No previous history of
Antiphospholipid Syndrome (APS ... BUT high-risk aPL ... history thrombotic APS ... history of obstetric APS ... non-criteria" obstetric APS