Pathophysiology - Renal compression as a mechanism of obesity hypertension. Compression of the thin loop of Henle by renal sinus fat may lead to increased sodium reabsorption in the thick ascending loop of Henle. This would lead to reduced sodium chloride delivery to the macula densa cells which (through a tubuloglomerular feedback mechanism) would increase secretion of renin and glomerular filtration, both of which are observed in obese individuals prior to nephron injury #Renal #compression #hypertension #obesity #pathophysiology
