Rhabdomyolysis - Differential Diagnosis Framework Rhabdomyolysis = Destruction of skeletal muscle with leakage of contents into circulation. What’s in muscle? Electrolytes (K, phos, uric acid) and proteins (CK, myoglobin, aldolase, AST/ALT, LDH). Differential Diagnosis: • Trauma: Crush injuries • Exertion: Strenuous exercise, Seizures, Delirium tremens • Hypoxia: Prolonged immobilization, Limb Compression • Genetic Defects: Glycolysis, Glycogenolysis, Lipid metabolism, Mitochondrial disorders • Infections: Influenza (A and B), Coxsackie virus, EBV, HIV, Legionella, Strep and Staph, Clostridium • Body Temperature: Heat stroke, Malignant hyperthermia, Neuroleptic malignant syndrome • Metabolic and Electrolytes: Hypokalemia, Hypophosphatemia, DKA/HHS, Hypothyroidism • Dugs: Lipid-lowering drugs (statins, fibrates), Colchicine, Alcohol, Opioids, Cocaine, Amphetamines, LSD UW IM Residency @uw_IMresidency #Rhabdomyolysis #Differential #Diagnosis #Causes #nephrology #table
