Satyendra Dhar, MD @DharSaty · 2 years ago
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Concentrated Insulin Developed with the goal of easing therapy by reducing the volume & number of injections
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Concentrated Insulin

Developed with the goal of easing therapy by reducing the volume & number of injections and in some cases making use of altered pharmacokinetic and pharmacodynamic properties
Benefits: 
 • Large volumes insulin approaching 100 U impedes absorption & are more painful compared with smaller volume injections. Low volume lead to low variability, leading to lesser risk of hypoglycemia.
 • Pts who require > 200 U of insulin/ day are considered to have severe IR. 
 • Available in pens, associated with a lower risk of dosing errors. 
 • High patient acceptability & has the potential for decreased volumes & frequency of injections.
 • Shown to significantly improve glycemic control comparing pre- and post-intervention periods in patients switched from U-100 prandial insulin preparations to U-500 regular insulin.

Satyendra Dhar, MD @DharSaty

#Concentrated #Insulin #pharmacology #conversion
Satyendra Dhar, MD @DharSaty · 2 years ago
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