Treatment of smallpox patients generally involves supportive care. Vaccination with replication-competent smallpox vaccines (i.e., ACAM2000 and APSV) can prevent or lessen the severity of disease if given within 2 to 3 days of the initial exposure. They may decrease symptoms if given within the first week of exposure. Treating smallpox patients in a healthcare setting requires isolation and adherence to proper infection and environmental controls. Antivirals There are three primary antiviral therapies that have shown effectiveness against orthopoxviruses including variola (the virus that causes smallpox) in animals and in vitro studies. However, there is no treatment for smallpox disease that has been tested in people who are sick with the disease and been proven effective in this population. #SmallPox #OrthoPox #Treatment #Tecovirimat #Brincidofovir #Cidofovir #Antivirals
