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Occult Causes of Non-Response to Vasopressors vital disclaimer: the cognitive response to hypotension should not be reaching for a vasopressor. the primary therapy for hypotension is treatment of the underlying pathology definition: patients who despite substantial vasopressor doses do not show HD parameter improvements. failure of response -> cognitive pause + consideration of reasons considerations for non-responders: - acidosis - hypothyroid - anaphylaxis - adrenal insufficiency - hypoCa2+ - occult bleeding - toxicologic - 2nd cause shock #Diagnosis #Nonresponse #Nonresponder #Multiple #Vasopressors #Differential #Causes #RebelEM #Refractory