Chemotherapy Toxicity Bear Mnemonic - Cumulatively Toxic Drugs and their Rescues • Asparagine: neurotoxicity • Cisplatin: ototoxic/nephrotoxic; Tx: Amifostine • Vincristine/Vinblastine: "Christ my nerves, Blast my bones" - Vincristine = peripheral neuropathy, Vinblastine = myelosuppression • Bleomycin: pulmonary fibrosis • Doxorubicin: cardiotoxic; Tx; Dexrozoxane (for cardiotoxicity), Dimethyl-sulphoxide (for ROS ulcers) • Cyclophosphamide: Acrolein = nephro/bladder toxic (Tx: Mesna); also SIADH effects (Tx: Demeclocycline) • Methotrexate: nephrotoxic (Tx: Leucovorin), myelosuppression (Tx: Filgrastim) Salim R. Rezaie, MD @srrezaie #Chemotherapy #Toxicity #Bear #Mnemonic #Drugs #pharmacology #oncology #SideEffects #Adverse

Richmond Agitation Sedation Scale +4 - Combative, Violent, Immediate Danger to Staff +3 - Very Agitated - Pulls or Removes Tube(s) or Catheter(s); Aggressive +2 - Agitated - Frequent non-PurposefuI Movement, Fights Ventilator +1 - Restless - Anxious, Apprehensive but Movements are not Aggressive or Vigorous 0 - Alert and Calm -1 - Not Fully Alert. but has Sustained to Voice (Eye Opening & Contact > 10 sec) -2 - Light Sedation - Briefly Awakens to Voice (Eye Opening & Contact < 10 sec) -3 - Moderate Sedation Movements or Eye Opening to Voice (BUT NO Eye Contact) -4 - Deep Sedation - No Response to Voice, BUT has Movement or Eye Opening to Physical Stimulation -5 - Unarousable - No Response to Voice or Physical Stimulation Stimulation REBEL Reviews #RASS #Richmond #Agitation #Sedation #Scale #diagnosis #criticalcare

REBEL Review #91: Management of Peripheral Pressor Extravasation #peripheralpressors #vasopressors #extravasation

Bougie-Assisted Cricothyrotomy Equipment Needed #cricothyrotomy #bougie #intubation #airwaymanagement

RCTs of Steroids Alone and Septic Shock #sepsis #septicshock #hydrocortisone #infectiousdisease

RCTs of the Metabolic Cocktail and Time Off Pressors #sepsis #vitaminc #septicshock #thiamine #hydrocortisone #infectiousdisease

RCTs of the Metabolic Cocktail and Mortality Outcomes #sepsis #vitaminc #septicshock #thiamine #hydrocortisone #infectiousdisease

This is an oversimplified, hypothetical model to think about time from symptom onset and stages of disease in COVID-19. This can help determine what treatments may be beneficial or harmful. #COVID19 #COVID #infectiousdisease #clinical #management #treatment

This is how to do a time-based N95 reuse strategy safely. place a label with the date last used and the next date that the mask can be used. #COVID19 #COVID #infectiousdiseases #N95 #management

This is a summary of 6 techniques for N95 decontamination and safe reuse cycles #COVID #COVID19 #management #infectiousdisease #N95