Depostion of glycosamineglycans (mucin) Filtration of albumin Nat retention + < Edema Effusion, hoarse voice, puffed-up face Impaired cerebral development Myxedema Neuromuscular excitability Sensory disturbances Hyporeflexia Lack of drive Depression Clouded consciousness VitaminA Sebaceous and sweat gland activity Dry, scaly skin Energy metabolism Heat metabolism Sensitivity to cold Appetite! Erythropoiesis Renal blood flow Glomerular filtration Transport Salt and water retention Delayed breakdown of VLDL Reduced bile secretion VLDL 1 Cholesterol 4 Reduced lipolysis Overweight Intestinal motility Constipation Reflux esophagitis Atherosclerosis Cardiac contractility Bradycardia Protein synthesis Elimination of drugs #Glycogenolysis #Gluconeogenesis Hypoglycemia In children: retarded longitudinal growth and delayed epiphyseal fusion somatotropin release Small stature Cretinism