Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis - Kupperman et al. NEJM 2018 https://www.nejm.org/doi/full/10.10 Study bottom line: Our traditionally cautious approach to fluid resuscitation in DKA is not supported. Though the very young and the very sick (generally our biggest causes for concern) may be lost in this cohort, the evidence that IV fluid administration is not the cause of brain injury in DKA is now stronger than anything that previously suggested it was. More interestingly it is perhaps now time to stop arguing over fluids and start trying to figure out what does cause brain injury in DKA. Visual Abstract by Dr. Tessa Davis @TessaRDavis #EBM #VisualAbstract #Peds #Pediatrics #DKA #IVFluids #Infusion #Rates #NEJM
