Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview Mechanism: binds ergosterol in membrane and forms membrane pores à fungicidal. Drug of choice for many severe fungal infections: Zygomycetes, Cryptococcal Meningitis (induction phase with flucytosine), Severe Histoplasmosis/Blastomycosis/Coccidioidomycosis 2nd-line for invasive aspergillosis (voriconazole is drug of choice). 2nd-line for candida infections – because echinocandins are at least as effective, and less toxic. #Pharmacology #Antibiotics #Review #Overview #Polyenes #Antifungal #AmphoterecinB #Abelcet #Ambisome
