Pulmonary Complications Following Stem Cell Transplant For patients in the pre- engraftment period (day 0-30): - Pulmonary infections - Pulmonary edema - Engraftment syndrome (typically within 10 days, more common with autologous transplant) - Diffuse alveolar hemorrhage (more common in allogenic than autologous) - Idiopathic pneumonia syndrome (more common in allo than auto) - Hyperacute/acute GVHD predominate. - TRALI/TACO due to transfusion support For patients in the early post- engraftment period (Engraftment day-100 days post engraftment): - Infectious more likely (viral- influenza, CMV, adenovirus, bacterial- pneumococcus, legionella, nocardia,actinomyces,mycobacteria, and fungal- PCP, aspergillus) - Idiopathic pneumonia syndrome - Drug toxicity/Radiation pneumonitis For patients in the post-engraftment period (day 100 onward): - Bronchiolitis obliterans - Organizing pneumonia - Malignancy - Pulmonary alveolar proteinosis/pulmonary cytolytic thrombi - Radiation pneumonitis - Autoimmune connective tissue disorders #Diagnosis #Differential #StemCell #Transplantation #Pulmonary #Complications #Timeline
