Sweat gland tumors - Pathology Made with lots of help from @JMGardnerMD's paper on adnexal tumors for the surgical pathologist, https://doi.org/10.5858/arpa.2018-0189-RA Dr. Laura Brown https://twitter.com/lauraebrown #Sweat #gland #tumors #Pathology #Diagnosis

Prolymphocytes In our case, the patient has T-prolymphocytic leukemia (T-PLL) not Acute Myeloid Leukemia (AML). 🔬Tumor cells are NOT blasts but 𝐩𝐫𝐨𝐥𝐲𝐦𝐩𝐡𝐨𝐜𝐲𝐭𝐞𝐬: small to medium size lymphoid cells with mature chromatin and with cytoplasmic protrusion or blebs - Daniela Hermelin, MD @HermelinDaniela #Prolymphocytes #Smear #Peripheral #Pathology #Microscopy #Clinical #Blood

Sickle cell anemia and Howell Jolly bodies (nuclear remnants). - Dr. Abubaker Elshaikh @ElshaikhMD #SickleCell #HowellJolly #Body #Bodies #Pathology #Hematology #Smear #Clinical #Microscopy

Beautiful acanthocytes/spur cells in a patient with McLeod Syndrome. X-linked disorder characterized by reduced expression of Kell RBC antigens and associated with chronic granulomatous disease. Makes transfusion very difficult. - Michael Moravek, MD @MoravekMD #acanthocytes #SpurCells #McLeod #Syndrome #Smear #Pathology #Microscopy #Clinical

The many faces of the Hodgkin/Reed-Sternberg (HRS) cell: Even as medical students we are aware of the archetypal binucleate Reed-Sternberg cell (RS cell). In reality, these textbook forms are not seen in every case of classical Hodgkin lymphoma. Many variants exist. - The Lymphomaniac - Matthew Pugh FRCPath @TheLymphomaniac #Hodgkins #Lymphoma #ReedSternberg #HRS #cell #Pathology #Clinical #Microscopy

How to distinguish a metamyelocyte from a band neutrophil. Metamyelocyte: The nucleus is indented to less than half of the potential round/oval nucleus Band neutrophil: The indentation is more than half of the potential round/oval nucleus - Kyle Bradley, MD @KyleBradleyMD #metamyelocyte #band #neutrophil #comparison #pathology #diagnosis #clinical

Pathology - Castleman disease. Mediastinal mass in a younger woman. Histologic Features of Castleman disease, hyaline vascular type - Increase in paracortical blood vessels - Germinal center 'twinning' = rnost specific feature - Hyalinized germinal centers with penetrati ngvessels - Suggestion of mantle zone 'onion skinning' - Michael Cascio, M.D. @mjcascio #Castleman #disease #Pathology #Smear #Microscopy #Clinical

Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not a morphologic one! Microangiopathic hemolytic anemia is characterized by an increase in: - spherocytes (blue arrow) - schistocytes (red arrow) - non-specific red cell fragments (black arrowhead) - polychromatophilic cells (black arrow) Peripheral smear changes are insensitive for conditions such as disseminated intravascular coagulation and other testing (platelet count, D-dimer, egg) are required for evaluation. - Michael Cascio, M.D. @mjcascio #MAHA #microangiopathic #hemolytic #anemia #Hematology #Pathology #Smear #Microscopy

Diffuse Sclerosis Variant—PTC - Rare variant of PTC - Approximately 3% ofall PTC - Common in children and young adults - May present as bilateral goiter - Ultrasound shows multiple calcifications (can be mistaken for chronic lymphocytic thyroiditis) - Cytology: • Carcinoma cells arranged in nests • Numerous psammoma bodies • Foci of non-psammomatous calcifications • Brisk lymphocytic infiltrate around the tumor cells • Squamoid change in tumor nests • Variable molecular profile- RET/PTC rearrangements (RET/PTCI > RET/PTC 3) & BRAF V600e mutations. RET/PTC3 in patients with advanced disease. • KIF5B/RET rearrangement is reported in a fatal tumor - Dr. Zubair Baloch @aakasharmand #Diffuse #Sclerosis #Variant #PTC #Papillary #Thyroid #Cancer #Pathology #Clinical #Gross #Microscopy

Here are the morphological hallmarks of Rhabdomyosarcoma. - Broken arrow sign - tad-pole rhabdomyoblasts - Wraith cells - Cross striations - Kemal Kösemehmetoğlu @dokemal #Rhabdomyosarcoma #Hallmarks #Pathology #Microscopy #Clinical