Hobnail variant of PTC: micropapillary architecture, dense eosinophilic cytoplasm, hobnail cells with apical nuclei, and marked nuclear pleomorphism beyond usual PTC atypia. Frequent BRAF V600E, TP53, and TERT promoter mutations. Aggressive behavior. - Dr. Lisa Rooper @LisaRooperMD #Hobnail #PTC #Papillary #Thyroid #Carcinoma #Pathology #Clinical #Microscopy
