Diffuse Sclerosis Variant—PTC - Rare variant of PTC - Approximately 3% ofall PTC - Common in children and young adults - May present as bilateral goiter - Ultrasound shows multiple calcifications (can be mistaken for chronic lymphocytic thyroiditis) - Cytology: • Carcinoma cells arranged in nests • Numerous psammoma bodies • Foci of non-psammomatous calcifications • Brisk lymphocytic infiltrate around the tumor cells • Squamoid change in tumor nests • Variable molecular profile- RET/PTC rearrangements (RET/PTCI > RET/PTC 3) & BRAF V600e mutations. RET/PTC3 in patients with advanced disease. • KIF5B/RET rearrangement is reported in a fatal tumor - Dr. Zubair Baloch @aakasharmand #Diffuse #Sclerosis #Variant #PTC #Papillary #Thyroid #Cancer #Pathology #Clinical #Gross #Microscopy
